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Scientists have discovered a new form of “ultra-bad” cholesterol that increases the risk of heart disease, a breakthrough they say could lead to a new class of anti-cholesterol treatments.
The super-sticky low-density lipoprotein (LDL), called MGmin-LDL, is often found in elderly people and those with Type 2 diabetes, according to researchers at the University of Warwick in England who made the discovery.
The fatty material, they said, is stickier than the common form of LDL or “bad” cholesterol, making it more likely to attach to artery walls, the Daily Mail reported.
Dr Naila Rabbani, who led the research, said: “We’re excited to see our research leading to a greater understanding of this type of cholesterol, which seems to help cause heart disease in diabetics and elderly people. It provides a possible explanation for the increased risk of coronary heart disease in people with diabetes.” Dr Rabbani hopes that it would lead to development of new anti-cholesterol drugs.
The MGmin-LDL, with sugary molecules smaller and denser than those of LDL, easily sticks to artery walls, providing a starting point for the build-up of fatty plaques, the researchers said. As the deposits grow, they narrow arteries and reduce blood flow. Eventually they can rupture, triggering a blood clot that causes a heart attack.
You can read this also at www.indianexpress.com/news/ultrabad-cholesterol-discovered/796691/
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